Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 22;8:12564. doi: 10.1038/s41598-018-30021-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Senofilcon A UVB blocking contact lenses prevent modifications in the expression of key inflammation and angiogenesis-related proteins produced by limbal epithelial cells and limbal fibroblasts. ELISA analysis of conditioned media from limbal epithelial cells and limbal fibroblasts for TNFα (A), MCP-1 (B), VEGFA (C) and VEGFC (D). UVB irradiation induced an upregulation of TNFα and MCP-1 (in limbal epithelial cells and limbal fibroblasts respectively) while this was prevented by the use of UVBCL lenses to protect the cultures (A,B). UVB irradiation of limbal epithelial cells induced a reduction in VEGFA and VEGFC (C,D) while covering of the cultures with UVBCL lenses maintained the protein levels similar to the ones of the controls. (n = 3, *p < 0.05, **p < 0.01 and ***p < 0.001 and ****p < 0.0001). Four asterisks (****) situated above bars without brackets correspond to significance in comparison to all other groups. (● signifies that the protein levels were under the detectable levels of the assay).