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. 2018 Aug 22;8:12552. doi: 10.1038/s41598-018-30675-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of white matter integrity in response to hypoperfusion. (a) There was no significant loss of white matter integrity between groups in the corpus callosum, (b) nor in the internal capsule (c) but there was a significant effect of cerebral hypoperfusion in the optic tract (F_(1,31) = 13.57, p = 0.001). (d) Fold change of white matter integrity loss compared to respective sham controls in the optic tract showed significantly more loss in wild type animals (p = 0.03). Dashed line indicates average sham level. (e) Representative images of MAG+ staining in the optic tract. Scale bar 100 µm. Mean ± SEM. (a–c) Two-way ANOVA with Bonferroni adjustment for post hoc analysis. (d) Unpaired one-tailed t-test. *p < 0.05, ** p < 0.01. n = 8–10 per group.