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. 2018 Aug 22;8:12552. doi: 10.1038/s41598-018-30675-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Astrogliosis in response to hypoperfusion was less severe in GFAP-Nrf2 animals. (a) % Area of GFAP+ staining in the corpus callosum and (b) internal capsule was unchanged following cerebral hypoperfusion. (c) % Area of GFAP+ staining in the optic tract was significantly increased by cerebral hypoperfusion (F_(1,32) = 38.87, p < 0.0001), with a significant effect of genotype (F_(1,32) = 7.45, p = 0.01). (d) Representative images of GFAP+ staining in the optic tract. Scale bar 100 µm. Mean ± SEM. Two-way ANOVA with Bonferroni adjustment for post hoc analysis. *p < 0.05, **p < 0.01, ***p < 0.001. n = 8–10 per group.