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. 2018 Aug 22;8:12552. doi: 10.1038/s41598-018-30675-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nrf2, Slc7a11 and Gclm relative gene expression is higher in GFAP-Nrf2 animals with no effect of hypoperfusion. (a) Nrf2, (b) Slc7a11 and (c) Gclm expression was significantly higher in GFAP-Nrf2 animals (F_(1,32) = 298, p < 0.0001, F_(1,32) = 74.05, p < 0.0001, F_(1,32) = 737.5, p < 0.0001; respectively), but this was not altered by hypoperfusion. Gene expression was normalised to Gapdh and expressed relative to WT sham controls. Dashed line indicates average WT sham level. Mean ± SEM. Two-way ANOVA. n = 8–10 per group.