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. 2018 Aug 16;9:1820. doi: 10.3389/fimmu.2018.01820

Figure 2.

Figure 2

The polymorphism of NKG2D ligands will affect the biological function of NKG2D ligands in multiple levels, including (A) different transcription, (B) different expression level on cell surface, (C) different binding affinity, (D) different soluble ligands shedding. Collectively, these will ultimately affect the (E) downstream signaling and cytotoxicity function.