Table 1.

The clinical relevance of polymorphism within NKG2D ligands.

	NKG2DL	Single nucleotide polymorphisms	Diseases	Reference
Malignancy association	MICA	129-Met/Val	Nasopharyngeal carcinoma	Douik et al. (34)
	MICA	MICA-5.1	Oral squamous cell carcinoma	Tamaki et al. (35, 36)
	MICA	MICA-5.1	Breast cancer	Lavado-Valenzuela et al. (37)
	MICA	213 thr and 251 gln	Cervical cancer	Jumnainsong et al. (38)
	MICA	rs2596542, rs2596538	Hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC)	Kumar et al. (39); Lo et al. (40); Goto et al. (41)
	MCIA	rs2596542G/A 129Met/Val; 251Gln/Arg 175Gly/Ser; triplet repeat	Hepatitis B virus-induced hepatocellular carcinoma	Tong et al. (42)
Virus infection	MICA	MICA-5.1	CMV reactivation in HIV-infected patients	Moenkemeyer et al. (43)
	MICB	rs3132468	Dengue shock syndrome and non-severe dengue	Khor et al. (44); Whitehorn et al. (45); Dang et al. (46)
Autoimmune diseases	MICA	129-Met/Val	Chronic Chagas heart disease	Ayo et al. (47)
	MICA	129-Met/Val	Ankylosing spondylitis	Amroun et al. (48)
	MICA	rs1051794	Rheumatoid arthritis	Kirsten et al. (49)
	MICA	129-Met/Val	Inflammatory bowel disease	Lopez-Hernandez et al. (50); Zhao et al. (51)
	MICA	129-Met/Val	Lupus erythematosus	Yoshida et al. (52)
	MICA	129-Met/Val	Type I diabetes	Raache et al. (53)
	MICA	129-Met/Val	Psoriatic disease	Pollock et al. (54)
	MICA	Triplet repeat microsatellite	Behçet disease	Mizuki et al. (33)
	MICA	MICA-A9 triplet repeat	Psoriatic arthritis	Gonzalez et al. (55)
	ULBP6	Rs1543547	Diabetic nephropathy	Mcknight et al. (56)
	ULBP6	Rs9479482	Autoimmune alopecia	Petukhova et al. (30)
HSCT	MICA	129-Met/Val	Chronic GvHD	Boukouaci et al. (57)
	ULBP6	ULBP0601/ULBP0602	HSCT overall outcome	Antoun et al. (58)
	MICA	129-Met/Val	HSCT clinical outcome	Isernhagen et al. (59)