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. 2018 Aug 22;9:3373. doi: 10.1038/s41467-018-05619-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Structure of the MRJP1 oligomer. a The H-like complex structure contains four MRJP1 (green or cyan), four apisimin (yellow or wheat), and eight 24-methylenecholesterol (blue, purple, orange, or lime sticks) molecules. N-acetylglucosamine (NAG) attached to Asn144 is shown in stick representation. The structure has two orthogonal twofold axes. Note that the stereoview is shown in the left and middle panels, a 90° rotation view in the right panel. The composite simulated-annealing mF_o—DF_c omit electron density maps of apisimin (b) and 24-methylenecholesterol (c) (also called Ostreasterol, Osl; formula shown in the right panel) are shown at 3.0 σ. The presence of apisimin (wheat arrow) was detected using tricine-SDS-PAGE