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. 2018 Mar 13;98(6):856–869. doi: 10.1093/biolre/ioy060

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© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

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Figure 5. — Absence of SPOP in the murine uterine results in a significant attenuation in the induction of established transcriptional responses to acute progesterone exposure. Quantitative real-time PCR analysis of the transcriptional induction of established P4 gene targets in the uterus from ovariectomized control and Spop^d/d mice treated with vehicle (sesame oil (white column)) and 1 mg P4 (1 mg/100 μl (black column)) for 6 h (n = 5 mice per treatment/genotype). Note the marked decrease in transcriptional induction of Areg; Hdc; Ihh; Plzf; Cyp26a1; Errfi1; IL13ra2; and Tcf23 in the Spop^d/d uterus in response to P4 administration. P values ≤0.05, ≤0.01 and ≤0.001 are indicated by *, **, and *** respectively; n.s. denotes nonspecific (P > 0.05).