Fig. 12.

α₇-Nicotinic receptors are protective in two-kidney-one-clip (2K1C) hypertension. Proinflammatory state (IL-6, IL-Iβ, and TNF-α), as well as cardiac hypertrophy [left ventricular weight/body weight (LVW/BW)] and glomerulosclerosis in 2K1C hypertension (WT; solid bars), are enhanced in α₇-nicotinic receptors of KO mice (shaded bars). nAChR, nicotinic ACh receptor. Values are means ± SE. *P < 0.05 and **P < 0.01 compared with sham (unpaired t-test). #P < 0.05 compared with WT (unpaired t-test). [From Li et al. (48) with permission from Wolters Kluwer Health.]