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Effects of IL-17A (C and D) and IL-17F (A and B) on endothelial dysfunction. Selective loss of cholinergic (ACh) endothelial-dependent vasorelaxation is seen with IL-17F (A) but not IL-17A (C). Neither 17F (B) nor 17A (D) reduced nonendothelial-mediated relaxation with sodium nitroprusside (SNP). Values are means ± SE. *Statistically significant difference (P < 0.05). [From Singh et al. (71) with permission from Elsevier.]
