TABLE 2.
Pharmacokinetic parameters of antimicrobials achieved in the PK/PD model
| Antimicrobial agent (dosage) | Cmax (μg/ml) (targeted value) | t1/2 (h) (targeted value) | AUC0–24 (μg · h/ml)a |
|---|---|---|---|
| Telavancin (7.5 mg/kg/day) | 84.75 ± 1.34 (84.75) | 7.17 ± 0.71 (8.1) | 819.86 ± 85.75 |
| Telavancin (10 mg/kg/day) | 99.30 ± 3.82 (108) | 8.32 ± 0.20 (8.1) | 1,136.26 ± 39.10 |
| Ceftaroline (600 mg q8h) | 21.25 ± 0.45 (21.3) | 2.71 ± 0.04 (3) | 83.75 ± 1.7 |
| Rifampin (450 mg q12h) | 10.58 ± 0.05 (10.54) | 2.98 ± 2.84 (2.66) | 43.62 ± 1.35 |
a
AUC0–24, AUC from 0 to 24 h.