TABLE 4.
Urine concentrations, cumulative amounts excreted, and renal clearance of fosfomycina
| Dosing regimen (n) | Mean ± SD |
|||||||
|---|---|---|---|---|---|---|---|---|
| Study day 1 |
Study day 3 |
Study day 5 |
Study day 7 |
|||||
| Avg urine concn over 24 h (μg/ml) | Cum Ae (mg) | CLR (liters/h) | Predose concn (μg/ml) | Avg urine concn over 24 h (μg/ml) | Cum Ae (mg) | CLR (liters/h) | Predose concn (μg/ml) | |
| QOD (18) | 361.7 ± 254.2 | 1,047.1 ± 710.5 | 7.1 ± 3.6 | 45.2 ± 84.2 | 434.6 ± 343.4 | 1,177.2 ± 790.8 | 7.5 ± 4.1 | 20.3 ± 32.9 |
| QD (18) | 342.4 ± 324.7 | 1,102.3 ± 772.7 | 8.1 ± 5.6 | 312.7 ± 263.3 | 387.9 ± 224.8 | 1,161.6 ± 718.1 | 7.3 ± 3.5 | 231.0 ± 227.6 |
a
QOD, every other day; QD, every day; Cum Ae, cumulative amount of fosfomycin excreted into urine over a 24-h collection period; CLR, renal clearance of fosfomycin.