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Piperaquine concentration-time profile (semilogarithmic scale) following administration of a full standard adult dose of dihydroartemisinin-piperaquine in step 2 (n = 40; ART-naive individuals, n = 10; individuals receiving efavirenz [EFV], n = 15; individuals receiving nevirapine [NVP], n = 15). Concentrations below the lower limit of quantification were excluded, resulting in a plotted observation time up to 336 h. Data are represented as the mean (95% confidence interval).
