TABLE 1.

Estimated parameter values from URSA Greco model in ADAPT 5 for each strain/phenotype

Parametera (drug)	Value (95% CI) for:
	H37Rv		18b
	Log phase	Acid phase	Log phase	NRP in acidic pH	NRP in neutral pH
ECON (log CFU/ml)	7.79 (7.07–8.51)	9.13 (6.19–12.1)	7.68 (7.31–8.06)	5.57 (5.12–6.02)	6.28 (5.95–6.61)
IC50,1 (LZD) (mg/liter)	4.72b (2.85–6.59)	2.0 (−1.31–5.31)	1.89b,c (1.60–2.18)	1.27b,c (0.994–1.54)	2.76c (2.36–3.16)
IC50,2 (BDQ) (mg/liter)	0.265d,e (0.230–0.301)	0.15 (−0.145–0.444)	0.855e (0.735–0.975)	0.760e (0.563–0.956)	0.701e (0.562–0.839)
m1 (LZD)	0.845 (0.489–1.20)	0.428 (0.179–0.676)	1.34 (1.08–1.61)	1.33 (1.04–1.61)	2.07 (1.59–2.56)
m2 (BDQ)	2.49 (1.24–3.74)	0.326 (0.224–0.428)	1.72 (1.23–2.21)	1.16 (0.87–1.45)	1.20 (0.974–1.42)

^aIC_50,1 and IC_50,2, concentration for half maximal effect; m₁ and m₂, Hill constant; E_CON, effect for the control.

^bP < 0.05 between H37Rv strain at log phase, 18b strain at log phase, and 18b strain at NRP phase in acidic pH environment for LZD.

^cP < 0.05 between 18b strain at log phase and 18b strain at NRP phase in acidic and neutral pH environments for LZD.

^dP < 0.05 between H37Rv strain at log phase, 18b strain at log phase, and 18b strain at NRP phase in acidic and neutral pH environments for BDQ.

^eP < 0.05 between IC_50,1 (LZD) and IC_50,2 (BDQ).