TABLE 1.
Summary of the isolates selected for the in vivo efficacy studies
| Isolate | JMI Laboratories isolate identifier | MIC (mg/liter) |
Positive molecular test results | Notes |
||||
|---|---|---|---|---|---|---|---|---|
| Plazomicin | Meropenem | Tigecycline | OmpC/OmpK36 | OmpF/OmpK35 | OmpK37 | |||
| Klebsiella pneumoniae 557 | 34215 | 2 | 8 | 0.5 | aadA2, blaTEM-1, blaSHV-11, aac(6′)-Ib, blaKPC-2, aph(3′)-Ia | Alterations | Disrupted | Alterations |
| Klebsiella pneumoniae 558 | 45846 | 2 | >32 | 1 | aac(3)-IId, aadA2, blaTEM-1, aph(6)-Ia, blaSHV-11, blaKPC-3, aph(6)-Id | Alterations | Disrupted | Alterations |
| Escherichia coli 471 | 31278 | 4 | 0.03 | ≤0.06 | aac(3)-IId, blaTEM-1, EC-6 (intrinsic AmpC) | Alterations | Wild type | NAa |
| Klebsiella oxytoca 92 | 41599 | 4 | ≤0.015 | 0.12 | blaOXY-6-4 (intrinsic gene) | Alterations | Alterations | Wild type |
| Citrobacter freundii 38 | 50925 | 4 | 0.06 | 0.5 | blaCMY-48-like (intrinsic gene), aac(6′)-If | Alterations | Alterations | NA |
| Morganella morganii 65 | 39292 | 8 | 0.06 | 1 | aac(3)-IId, blaDHA-9 (intrinsic gene), aadA5, aph(3′)-Ia | Wild type | NA | NA |
| Klebsiella pneumoniae 561 | 51020 | 8 | >32 | 2 | blaTEM-1, blaSHV-11, aac(3)-IIa, blaCTX-M-15, aac(6′)-Ib-cr, blaOXA-48, blaOXA-1, blaOXA-30 | Alterations | Disrupted | Alterations |
| Klebsiella pneumoniae 559 | 51015 | 16 | >32 | 2 | blaTEM-1, blaSHV-11, aac(3)-IIa, blaCTX-M-15, aac(6′)-Ib-cr, blaOXA-48, blaOXA-1, blaOXA-30 | Alterations | Disrupted | Alterations |
a
NA, not applicable.