TABLE 2.

Plazomicin AUC_0–24 and tigecycline fAUC_0–24 values in mice and humans

Agent	Species	Daily dose	Regimen	AUC0–24 or fAUC0–24 (mg · h/liter)
Plazomicin	Human	15 mg/kg q24h	Plazomicin	265.00a
	Mouse	28 mg/kg q24h	Plazomicin alone	269.06
			Plazomicin + meropenem	284.98
			Plazomicin + tigecycline	259.96
Tigecycline	Human	50 mg q12h	Tigecycline	0.94b
	Mouse	1.66 mg/kg q12h	Tigecycline alone	0.83
		1.66 mg/kg q12h	Tigecycline + plazomicin	0.55
		2 mg/kg q12h	Tigecycline + plazomicin	0.96
		2 mg/kg q12h	Tigecycline alone	1.34

^aCorresponding to an AUC_0–24/MIC of 132.5 to 16.6 for isolates with plazomicin MICs of 2 to 16 mg/liter.

^bCorresponding to an fAUC_0–24/MIC of 15.7 to 0.47 for isolates with tigecycline MICs of 0.06 to 2 mg/liter.