TABLE 1.
MICs of MRX-I compared to INH, LZD, SZD, and TZD against 22 isolates of Mycobacterium tuberculosisa
| Mycobacterium tuberculosis isolate, MIC50, or MIC90 | MIC (μg/ml) |
||||
|---|---|---|---|---|---|
| INH | LZD | SZD | TZD | MRX-I | |
| Erdman | 0.06 | 1 | 1 | 0.25 | 1 |
| H37Rv | 0.06 | 0.5 | 0.25 | 0.125 | 0.5 |
| 532 | 0.06 | 0.5 | 0.5 | 0.125 | 1 |
| 277 | 0.06 | 1 | 0.25 | 0.125 | 1 |
| 365 | 0.06 | 0.5 | 0.25 | 0.125 | 1 |
| 764 | 0.06 | 0.5 | 0.25 | 0.125 | 1 |
| AH517 | 0.03 | 1 | 0.5 | 0.25 | 1 |
| HN878 | 0.06 | 1 | 0.5 | 0.5 | 2 |
| 676 | 0.06 | 1 | 0.5 | 0.5 | 2 |
| BW9 | 0.06 | 1 | 0.5 | 0.5 | 1 |
| 487 | 0.03 | 0.5 | 0.5 | 0.125 | 1 |
| C913 | 0.06 | 0.5 | 0.5 | 0.125 | 0.5 |
| CDC1551 | 0.03 | 0.5 | 0.25 | 0.125 | 0.5 |
| S1863 | 0.03 | 0.5 | 0.25 | 0.125 | 0.5 |
| 5 | 1 | 0.5 | 0.5 | 0.125 | 0.5 |
| 56 | 2 | 0.5 | 0.5 | 0.125 | 0.5 |
| 265 | 1 | 0.5 | 0.5 | 0.25 | 0.5 |
| 258 | 2 | 0.5 | 0.5 | 0.125 | 0.5 |
| 352 | 2 | 0.5 | 0.25 | 0.125 | 0.5 |
| C-31 | 4 | 0.25 | 0.125 | 0.125 | 0.25 |
| 5037 | >8 | 1 | 0.5 | 0.25 | 1 |
| S982 | 8 | 1 | 0.5 | 0.25 | 1 |
| MIC50 | 0.06 | 0.5 | 0.5 | 0.125 | 0.5 |
| MIC90 | 4 | 1 | 0.5 | 0.5 | 1 |
a
MRX-I, contezolid; INH, isoniazid; LZD, linezolid; SZD, sutezolid; TZD, tedizolid. The MIC50 and MIC90 are defined as the concentrations at which 50% and 90% of the clinical isolates tested were inhibited, respectively.