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Metabolism of isoniazid in the liver. Isoniazid is metabolized by acetylation to acetylhydrazine and diacetylhydrazine. Acetylhydrazine can be hydrolyzed further to become isoniazid hydrazine, which also results from the hydrolysis of isoniazid itself. Isoniazid hydrazine is toxic to hepatocytes, and so are the more toxic reactive metabolites further derived from it through the activities of cytochrome P450 enzymes.
