TABLE 2.
β-Lactamase | CTX MIC (μg/ml) | CTX + Cpd1 MIC (μg/ml) | Cpd1 MIC reduction (μg/ml) | CTX + Cla MIC (μg/ml) | Cla MIC reduction (μg/ml) |
---|---|---|---|---|---|
E. coli CTX-M-1 | 256–128 | 64–32 | 4 | 0.25 | 1,024–512 |
E. coli CTX-M-15 | 64 | 16 | 4 | 0.12 | 512 |
K. pneumoniae CTX-M-2 | 512–256 | 64–32 | 8 | 0.5 | 1,024–512 |
E. coli CTX-M-8 | 32–16 | 16–8 | 2 | 0.06 | 512–256 |
E. coli CTX-M-9 | 128 | 16 | 8 | 0.12 | 1,024 |
E. coli CTX-M-14 | 64 | 8 | 8 | 0.06 | 1,024 |
E. coli SHV-5 | 16 | 16 | 0.06 | 256 | |
E. coli TEM-24 | 4 | 2 | 2 | 0.06 | 64 |
E. coli AmpC | 8 | 4 | 2 | 8 | |
E. coli OXA-48 | 0.5 | 0.25 | 2 | 0.5 | |
E. coli NDM-1 | 32 | 32 | 32 | ||
K. pneumoniae KPC-2 | 16 | 16 | 0.5 | 32 |
CTX, cefotaxime; Cpd1, compound 1; Cla, clavulanate. Cefotaxime plus compound 1 and cefotaxime plus clavulanate were used at a 1:1 ratio.