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Effect of efflux pump blocker on clofazimine efficacy. The bacterial burden in HFS-Mkn treated with the human-equivalent clofazimine dose of 100 mg/day in combination with reserpine was 0.56-log10 CFU/ml lower than that achieved with clofazimine alone and 0.95-log10 CFU/ml lower than that achieved in the nontreated HFS-Mkn on day 21.
