TABLE 2.

Parameter estimates for the final solithromycin population pharmacokinetic model^a

Parameter	Final model		Bootstrap analysis (n = 1,000)b
	Estimate	RSE (%)	2.5th percentile	Bootstrap · median	97.5th percentile
Structural model
Ka (h−1)	0.381	14	0.294	0.388	0.538
CLPOP,70 kg (liters/h)	55.0	15	40.2	51.3	69.8
VcPOP,70 kg (liters)	162	13	113.7	156.3	223.1
QPOP,70 kg (liters/h)	23.4	30	9.1	26.1	46.2
VpPOP,70 kg (liters)	119	14	90.2	122.4	161.3
F (%), capsule	69.1	19	41.1	70.2	94.1
F (%), suspension	52.9	20	34.1	51.9	75.8
Lag (h), capsule	0.494	2	0.458	0.495	0.564
Lag (h), suspension	0.365	24	0.196	0.388	0.478
Hill	1.1	63	0.612	1.6	7.1
TM50 (wk)	52.6	37	32.6	50.2	68.5
IIV (% CV)
IIV CL	81.9	8	67.8	82.3	105.2
Covariance CL-Vc	0.569	25	0.310	0.558	1.5
IIV Vc	89.6	13	58.3	87.6	159.0
Covariance Vc-Vp	0.262	38	0.057	0.247	0.563
IIV Vp	53.7	28	31.5	56.3	108.0
Covariance CL-Vp	0.355	38	0.110	0.357	0.849
Residual error (% proportional error)	53.9	9	48.8	52.8	57.7

^aCL_{POP,70 kg}, population clearance estimate scaled to a 70-kg adult; covariance CL-V_c, covariance between CL and V_c; covariance CL-V_p, covariance between CL and V_p; covariance V_c-V_p, covariance between V_c and V_p; F, bioavailability; Hill, Hill coefficient for the sigmoidal maturation function; IIV CL, interindividual variability in drug clearance; IIV V_c and V_p, interindividual variability in the central and peripheral compartments, respectively; K_a, absorption rate constant; Lag, lag time (in hours) in drug absorption; Q_{POP,70 kg}, population intercompartmental clearance estimate scaled to a 70-kg adult; RSE, relative standard error; TM₅₀, maturation half-life calculated as a function of postmenstrual age (weeks); V_{cPOP,70 kg}, population volume of distribution in the central compartment estimate scaled to a 70-kg adult; V_{pPOP,70 kg}, population volume of distribution in the peripheral compartment estimate scaled to a 70-kg adult.

^bA total of 1,000 bootstrap runs were performed (total minimized successfully = 832 [83%]).