FIG 5.
Portal and jugular plasma concentrations versus time for GS2 following oral administration to portal vein-cannulated male beagle dogs (5 mg/kg; solution) (means ± standard deviations, n = 3). (A) The portal (closed circle) and jugular (open circle) plasma concentrations are shown. GS2 showed an Fa (faction absorbed) value of 52% and an EH (hepatic extraction) value of 75%. (B) Portal plasma concentration versus time for GS2 (5 mg/kg; solution) and GS-6620 (5 mg/kg; suspension of micronized material) following oral administration to portal vein-cannulated male beagle dogs (means ± standard deviations, n = 3).