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Specific activity for ester cleavage of GS-6620 and GS2 by CatA, CES1, and CES2
| Compounda | Amidate ester cleavage (pmol/min · μg) |
3′-Ester cleavage (pmol/min · μg) |
|||
|---|---|---|---|---|---|
| CatA | CES1 | CES2 | CES1 | CES2 | |
| GS2 | 385 | 91.0 | Stable | NAb | NA |
| GS-6620 | 4,163 | 1.9 | Stable | 1.6 | 60.1 |
Specific activity cannot be compared between enzymes because the assays have been optimized differently. GS-6620-containing diastereomeric mixture was used.
NA, not applicable.
