Figure 2.

Distribution of CYP2B6 level frequencies in cases. CIs were calculated using the modified Wald method. (a) Frequencies of CYP2B6 metabolizer genotype levels in CNS cases based on 10 possible levels (n = 43). (b) Frequencies of CYP2B6 metabolizer genotype levels in CNS cases collapsed into extensive, intermediate and slow metabolizer groups. (c) Frequencies of CYP2B6 metabolizer genotype levels in all-cause cases based on 10 possible levels (n = 89). (d) Frequencies of CYP2B6 metabolizer genotype levels in all-cause cases collapsed into extensive, intermediate and slow metabolizer groups. EXT, extensive metabolizer genotypes; INT, intermediate metabolizer genotypes; SLO, slow metabolizer genotypes. CYP2B6 genotype levels were collapsed as follows: extensive (levels 1 and 2), intermediate (levels 3, 4, 5, 6 and 7) and slow (levels 8, 9 and 10).²⁰