Table 2.

Significant associations between SNPs and efavirenz CNS adverse effects

Genotype	Casesa	Controlsa	Unadjusted model OR (95% CI)	Adjusted model OR (95% CI)c
SNP rs1882478 (ABCB1)
CC	7 (0.17)	41 (0.31)	reference	reference
CT	22 (0.52)	72 (0.54)	1.79 (0.70–4.55)	1.50 (0.54–4.17)
TT	13 (0.31)	20 (0.15)	3.81 (1.32–11.02)	2.62 (0.80–8.65)
	42	133	P = 0.040b	P = 0.267b
CC-CT	29 (0.69)	113 (0.85)	reference	reference
TT	13 (0.31)	20 (0.15)	2.53 (1.13–5.69)	1.94 (0.79–4.80)
			P = 0.027d	P = 0.156d
SNP rs4646437 (CYP3A4)
GG	6 (0.17)	47 (0.41)	reference	reference
GA	16 (0.46)	46 (0.40)	2.72 (0.98–7.58)	3.09 (0.96–9.95)
AA	13 (0.37)	22 (0.19)	4.63 (1.55–13.79)	4.95 (1.22–20.05)
	35	115	P = 0.014b	P = 0.059b
GG	6 (0.17)	47 (0.41)	reference	reference
GA-AA	29 (0.83)	68 (0.59)	3.34 (1.29–8.68)	3.36 (1.07–10.59)
			P = 0.007d	P = 0.029d
SNP rs2740574 (CYP3A4)
TT	14 (0.39)	60 (0.51)	reference	reference
TC	12 (0.33)	42 (0.36)	1.22 (0.52–2.91)	1.03 (0.39–2.70)
CC	10 (0.28)	15 (0.13)	2.86 (1.06–7.68)	2.02 (0.60–6.79)
	36	117	P = 0.116b	P = 0.435b
TT-TC	26 (0.72)	102 (0.87)	reference	reference
CC	10 (0.28)	15 (0.13)	2.62 (1.05–6.49)	1.98 (0.71–5.52)
			P = 0.043d	P = 0.198d

^aResults are shown as n (frequency) for SNP genotypes.

^bOverall P value for additive model (2 degrees of freedom).

^cResults adjusted for sex, African ancestry and Native American ancestry.

^dOverall P value for dominant or recessive model (1 degree of freedom).