Table 3.
Association between CYP3A4 rs4646437 and rs2740574 and CNS adverse effects due to efavirenz
| Haplotype rs4646437/rs2740574 | Controlsa | Casesa | Unadjusted model OR (95% CI) | Adjusted model OR (95% CI)b |
|---|---|---|---|---|
| G/T | 0.6 | 0.39 | reference | reference |
| A/C | 0.29 | 0.43 | 2.04 (1.17–3.56; P = 0.012) | 2.08 (1.02–4.26; P = 0.045) |
| A/T | 0.1 | 0.16 | 2.70 (1.09–6.70; P = 0.033) | 2.94 (1.06–8.15; P = 0.04) |
| G/C | 0.01 | 0.02 | 1.99 (0.18–21.42; P = 0.571) | 1.83 (0.15–22.02; P = 0.634) |
a
Haplotype frequencies were estimated by maximum likelihood.
b
Results adjusted for sex, African ancestry and Native American ancestry.