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(a) Impact of increasing dose on rifampicin AUC. With increasing dose, there appears to be a greater than proportional increase in AUC. Error bars show SEM. Data are displayed in Table 3. (b) Impact of increasing dose on rifampicin AUC/MIC. Taking the ECOFF MIC of 0.5 mg/L, available data indicate that a rifampicin dose of ≥25 mg/kg is required to attain the PK/PD target associated with a 1 log cfu reduction (an AUC/MIC of 271).
