FIG 4.

Protective efficacy against a transgenic sporozoite challenge using a combination of the Rv21 and vvTRAP, in the presence of Matrix-M or AddaVax adjuvants. Inbred BALB/c mice (n = 6 per group) vaccinated with Rv21 and/or vvTRAP as described in Table 1 were challenged by intravenous administration of transgenic P. berghei PvCSP-VK210/PvTRAP double-replacement parasites using a stringent challenge with 2,000 sporozoites. (A) Efficacy of a vaccine consisting of Rv21 combined with either vvTRAP or of vvTRAP plus the adjuvant Matrix-M (MM) or AddaVax (Add). (B) Efficacy of Rv21 in the presence of chemical adjuvants. (C) Efficacy of a prime-boost vaccination regimen using vvTRAP. (D) Efficacy of a P. vivax CSP protein in combination with vvTRAP and Matrix-M adjuvants.