FIG 1.

Stimulation of antimicrobial protein gene expression in oral epithelial cells by IL-36γ. (A to C) Basal mRNA expression levels of the indicated PGLYRP (A), hBD (B), and S100A (C) proteins were measured (n = 3). (D to H) TIGK cells were stimulated with IL-36γ (100 ng/ml) for the time indicated. PGLYRP2 (D), PGLYRP4 (E), hBD2 (F), S100A8 (G), and S100A9 (H) mRNA levels were then measured (n = 3). (I and J) TIGK cells were stimulated with IL-36α (100 ng/ml) or IL-36γ (100 ng/ml) for 2 h. PGLYRP2 (I) and hBD2 (J) mRNA levels were then measured (n = 3). ***, P < 0.001; **, P < 0.01; *, P < 0.05.