Table 1.
Demographic and other baseline characteristics
| Cohort 1 | Cohort 2 | Cohort 3 | Cohort 4 | Cohort 5 | Cohort 6 | |
|---|---|---|---|---|---|---|
| (n = 12) | (n = 12) | (n = 12) | (n = 12) | (n = 12) | (n = 12) | |
| Age, mean (s.d.), years | 41.1 (10.6) | 44.7 (16.2) | 44.2 (8.2) | 43.2 (9.8) | 48.1 (12.8) | 44.4 (13.8) |
| Body weight, mean (s.d.), kg | 82.27 (14.14) | 78.48 (16.84) | 74.16 (8.62) | 78.47 (11.8) | 78.96 (10.94) | 73.83 (6.05) |
| BMI, mean (s.d.), kg/m2 | 28.1 (4.5) | 27.5 (5.3) | 24.9 (2.5) | 27.1 (4.2) | 27.4 (3.4) | 25.2 (2.6) |
| Gout, n (%) | 5 (41.7) | 6 (50.0) | 6 (50.0) | 7 (58.3) | 6 (50.0) | 7 (58.3) |
| Asymptomatic hyperuricaemia, n (%) | 7 (58.3) | 6 (50.0) | 6 (50.0) | 5 (41.7) | 6 (50.0) | 5 (41.7) |
| sUA, screening, mean (s.d.), mg/dl | 9.17 (1.09) | 8.56 (0.60) | 8.53 (0.74) | 8.99 (0.95) | 8.57 (0.61) | 8.86 (0.85) |
| eGFR, mean (s.d.), ml/min | 119 (19.7) | 120 (32.2) | 113 (19.7) | 106 (23.8) | 105 (24.0) | 107 (22.2) |
eGFR= [(140 − age) × ideal body weight (kg)]/[72 × serum creatinine (mg/dl)]. eGFR: estimated glomerular filtration rate based on serum creatinine, age and ideal body weight; sUA: serum urate.