Table 2. Univariate and multivariate analysis of factors influencing disease free survival (DFS) after surgical resection.
| Variable | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| 5-year rate (%) | P value | HR (95% CI) | P value | ||
| PD-L1 expression | 0.013 | 0.042 | |||
| Non-over | 57.7 | 1 (referent) | |||
| Over | 28.7 | 1.713 (1.020–2.880) | |||
| PD-L2 expression | 0.101 | 0.277 | |||
| Non-over | 44.6 | 1 (referent) | |||
| Over | 32.7 | 1.319 (0.801–2.173) | |||
| Age (years) | 0.275 | ||||
| <65 | 34.1 | ||||
| >65 | 47.0 | ||||
| Gender | 0.334 | ||||
| Male | 39.3 | ||||
| Female | 48.0 | ||||
| Smoking | 0.091 | 0.097 | |||
| No | 49.4 | 1 (referent) | |||
| Yes | 30.1 | 1.485 (0.931–2.369) | |||
| Tumor length (cm) | 0.166 | ||||
| <4 | 45.0 | ||||
| >4 | 34.1 | ||||
| Differentiation | 0.147 | ||||
| Well | 41.0 | ||||
| Moderate | 40.1 | ||||
| Poorly | 23.7 | ||||
| No mention | 48.5 | ||||
| pT status | 0.045 | 0.988 | |||
| T1–2 | 55.9 | 1 (referent) | |||
| T3–4 | 34.2 | 0.994 (0.437–2.260) | |||
| pN status | 0.002 | 0.531 | |||
| N0 | 56.7 | 1 (referent) | |||
| N1–3 | 29.2 | 1.351 (0.527–3.461) | |||
| Pathological stage | <0.001 | <0.001 | |||
| I–II | 60.1 | 1 (referent) | |||
| III–IV | 22.5 | 2.507 (1.499–4.194) | |||
| Post-op adjuvant treatment | 0.039 | 0.279 | |||
| No | 46.7 | 1 (referent) | |||
| Yes | 30.5 | 1.340 (0.789–2.274) | |||
HR, hazard ratio; CI, confidence interval; PD-L1, programmed death ligand-1; PD-L2, programmed death ligand-2.