Table 2.
Abdominal aorta hemodynamics, diameter, and stiffness measurements
| Abdominal aorta | WKY | SHRSP | SHRSP + clonidine | SHRSP-salt | SHRSP-salt + clonidine |
|---|---|---|---|---|---|
| Mean AP, mm Hg | 129±2 | 192±6* | 128±3 | 200±5* | 129±1 |
| Systolic AP, mm Hg | 156±1 | 226±9* | 155±3 | 234±5* | 156±3 |
| Diastolic AP, mm Hg | 109±2 | 163±5* | 107±3 | 174±4* | 110±1 |
| Heart rate, beats/min | 348±16 | 375±7 | 337±9 | 399±8* | 359±17 |
| Pulse pressure, mm Hg | 47±2 | 64±4* | 48±1 | 59±2* | 46±2 |
| Local PWV, m/s | 6.3±0.1 | 10.9±0.4* | 7.0±0.3 | 12.9±0.8* | 8.1±0.2*, # |
| Mean diameter, µm | 1,434±16 | 1,369±49 | 1,307±47 | 1,484±64 | 1,457±50 |
| Diastolic diameter, µm | 1,344±19 | 1,288±66 | 1,228±47 | 1,424±68 | 1,403±47# |
| Aortic distension, µm | 102±5 | 45±4 | 78±6 | 34±4 | 64±4 |
| Aortic distension, % | 7.6±0.4 | 3.5±0.3* | 6.4±0.5 | 2.5±0.3*, # | 4.5±0.3*, # |
| Compliance, mm2/kPa ×10−3 | 37.4±1.2 | 11.6±1.5* | 24.7±1.7* | 10.4±1.4* | 23.8±1.4* |
| Distensibility, 1/kPa ×10−3 | 24.2±1.0 | 8.2±0.6* | 19.8±1.5* | 6.3±0.8* | 15.0±1.0*, # |
| Stiffness index | 5.0±0.2 | 10.2±0.7* | 6.2±0.4 | 13.4±1.4* | 8.0±0.4*, # |
| Pulse pressure, AUCpp/ms | 20.3±1.0 | 28.6±1.6* | 20.8±0.3 | 25.3±1.4* | 18.0±1.0 |
| Distension, AUCd/ms ×10−1 | 3.9±0.2 | 1.8±0.1* | 3.2±0.2 | 1.2±0.1*, # | 2.1±0.1 |
| Distensibility index ×10−2 (AUCd/AUCpp) | 19.1±0.8 | 6.3±0.4* | 15.3±1.1* | 4.9±0.6* | 12.0±08* |
| Compliance index | 17.8±0.6 | 8.9±0.6* | 14.0±0.6* | 7.4±0.8* | 11.1±0.8*, # |
| n | 6 | 6 | 6 | 8 | 7 |
Parameters measured and calculated via the echotracking at the abdominal aorta. Results are expressed as mean ± SEM. AP, arterial pressure; PWV, pulse wave velocity.
*
Significantly different (p < 0.05) compared to WKY
#
significantly different (p < 0.05) compared to SHRSP.