Figure 4.

Acute NMUR2 agonists decrease food intake. (A) NY0116 did not significantly reduce 24‐hour standard diet intake at either dose (3 or 30 mg/kg, n = 8 for both groups). (B) NY0128 at both doses (3 mg/kg, n = 8; 30 mg/kg, n = 6) significantly suppressed standard diet intake over 24 hours compared to vehicle (n = 10). (C) NY0116 at both doses (9 or 90 mg/kg, n = 6 for each group) significantly suppressed high‐fat diet intake compared to vehicle (n = 10). (D) NY0128 at both doses (3 or 30 mg/kg, n = 6) also significantly suppressed high‐fat diet intake compared to vehicle. Error bars represent standard error of the mean. *P < 0.05 vs vehicle time‐point (repeated measures anova followed by Bonferroni posttest). NMUR1/2, NMU receptor ½