Figure 5.

Repeat administration of NMUR2 agonists decrease body weight and visceral adipose tissue. (A‐B) Mouse body weight decreased in a dose‐dependent manner with administration of NMUR2 agonists. (C) Representative images of micro‐CT data at the L5 vertebrae displaying visceral adipose tissue (white arrow). (D) NY0128 at 30 mg/kg decreased percentage of visceral adipose tissue at L5, compared to vehicle (n = 8–10 for each group). (E) Mouse food intake was not significantly changed by repeated administration of the NMUR2 agonists. Error bars represent standard error of the mean. *P < 0.05 vs vehicle ***P < 0.001 vs vehicle (A) repeated measures anova with Dunnett's posttest, (B–D) one‐way anova followed by Dunnett's posttest). NMUR1/2, NMU receptor ½