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It shows the EC50 and Emax (relative to NMS) values of NMS, NY0116, and NY0128 when evaluated in Gq mode. The EC50 and Emax values for NMS in a beta‐arrestin recruitment assay are also provided
| Calcium EC50 (nmol/L) | Calcium EMAX (RFU) | b‐Arrestin EC50 (nmol/L) | b‐Arrestin EMAX (% NMS) | |
|---|---|---|---|---|
| NMS | ND | ND | 1170 nmol/L ± 80 | 100% |
| NY0116 | 32 700 nmol/L ± 1100 | 2185 ± 205 | NA | NA |
| NY0128 | 16 900 nmol/L ± 900 | 2036 ± 186 | NA | NA |
NMS, neuropeptide neuromedin S.
