Table 4.
Association of MBL gene polymorphisms in different ethnic populations to TB.
| MBL2 | Population/Country | Allele/Haplotype | Association | Sample size | References | |
|---|---|---|---|---|---|---|
| HCs | PTB | |||||
| Exon1 (Codon 52, 54 and 57) | South Indian | Mutant homozygous | Susceptibility | 109 | 202 | (210) |
| Exon 1, codon-52 | Chinese | Heterozygous | Susceptibility | 198 | 125 | (211) |
| −221Y/X | South Indian | O/O genotype YA/YA diplotype | Susceptibility Susceptibility to TB in HIV | 146 | 148 | (212) |
| Codon 54, 57 | Turkish | AB genotype | Protection | 99 | 27 | (213) |
| Exon 1 −550(H/L) −221(X/Y) +4(P/Q) | Italian | HYA-HYA (Haplotype) LYB-LYD (Haplotype) | Protection Susceptibility | 288 | 277 | (214) |
| Exon 1 Codon54(A/B) | Indian | B' allele | Protection | 392 | 286 | (215) |
| −221(Y/X) Exon 1 Codon57(A/C) | Brazilian | X/Y genotype ‘O' allele ‘C' allele and ‘AC' genotype | Susceptibility Susceptibility Susceptibility | 148 | 155 | (216) |
| Exon1 codon 54(A/B) +4 (P/Q) | Chinese | 54 ‘B' allele +4 ‘P/Q' | Susceptibility No association | 1190 | 1106 | (217) |
| rs7096206(C/G) rs6695096(T/C) rs2273346(T/C) | Chinese | ‘CG' genotype ‘TC' genotype ‘TC' genotype | Susceptibility Susceptibility Susceptibility | 216 419 | 205 503 | (218)(219) |
| −550 (H/L) Codon 52 (A/B) +4 (P/Q) −221 (X/Y) | Chinese | HL genotype HPYA, LPXA, LQYA & LPYB (Haplotypes) | Protection Susceptibility | 453 | 151 | (136) |
| Exon 1 (Codon 54 and 57) | Turkish | No association | 50 | 50 | (139)(220) | |
| Exon1 Codon 52,54 and 57 | West Africa | No association | 2346 | 2010 | (221) | |
MBL, Mannose binding lectin.