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. 2018 Aug 22;15:234. doi: 10.1186/s12974-018-1264-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Serum levels of ALT (U/L). a, b Serum ALT levels were significantly higher in the LPS/D-GalN group (a) and TNF-α/D-GalN group (b). c In the anti-TNF-α IgG group, serum ALT levels decreased rapidly compared to those in LPS/D-GalN-treated mice. Data represent means ± SEM (n = 5 per group). *P < 0.05 vs. N.S. group, **P < 0.01 vs. N.S. group, #P < 0.01 vs. D-GalN+LPS 12 h group. ALT alanine transaminase, D-GalN d-galactosamine hydrochloride, LPS lipopolysaccharide, TNF-α tumor necrosis factor-alpha, N.S. normal saline