Table 2.
Significant superpathways and subpathways in pathway enrichment analysis
| Pathway | Number | Different | Percentage (%) | Upa | Downa | P | FDR-q |
|---|---|---|---|---|---|---|---|
| Superpathway | |||||||
| Lipid | 321 | 61 | 19 | 37 | 24 | 2.18E-56 | 1.75E-55 |
| Amino acid | 158 | 22 | 13.92 | 19 | 3 | 7.37E-19 | 2.95E-18 |
| Xenobiotics | 97 | 10 | 8.77 | 10 | 0 | 9.41E-09 | 2.51E-08 |
| Carbohydrate | 21 | 8 | 38.09 | 7 | 1 | 4.04E-07 | 8.08E-07 |
| Cofactors and vitamins | 20 | 5 | 25 | 0 | 5 | 1.07E-04 | 1.71E-04 |
| Nucleotide | 30 | 4 | 13.33 | 2 | 2 | 6.76E-04 | 9.01E-04 |
| Energy | 9 | 2 | 22.22 | 2 | 0 | 2.64E-02 | 3.02E-02 |
| Subpathway | |||||||
| Lysolipid | 24 | 10 | 41.67 | 10 | 0 | 1.91E-07 | 7.84E-06 |
| Phospholipid Metabolism | 33 | 8 | 24.24 | 8 | 0 | 4.47E-06 | 9.17E-05 |
| Fatty Acid Metabolism (Acyl Carnitine) | 23 | 7 | 30.43 | 0 | 7 | 2.14E-05 | 1.75E-04 |
| Food Component/Plant | 31 | 7 | 22.58 | 7 | 0 | 2.14E-05 | 1.75E-04 |
| Phenylalanine and Tyrosine Metabolism | 29 | 7 | 24.14 | 6 | 1 | 2.14E-05 | 1.75E-04 |
| Polyunsaturated Fatty Acid (n3 and n6) | 13 | 6 | 46.15 | 1 | 5 | 1.02E-04 | 6.94E-04 |
| Diacylglycerol | 19 | 5 | 26.32 | 5 | 0 | 4.79E-04 | 2.80E-03 |
| Fatty Acid, Monohydroxy | 14 | 4 | 28.57 | 2 | 2 | 2.24E-03 | 8.35E-03 |
| Hemoglobin and Porphyrin Metabolism | 5 | 4 | 80.00 | 0 | 4 | 2.24E-03 | 8.35E-03 |
| Leucine, Isoleucine and Valine Metabolism | 24 | 4 | 16.67 | 3 | 1 | 2.24E-03 | 8.35E-03 |
| Steroid | 36 | 4 | 11.11 | 0 | 4 | 2.24E-03 | 8.35E-03 |
| Endocannabinoid | 5 | 3 | 60.00 | 0 | 3 | 1.04E-02 | 3.05E-02 |
| Fructose, Mannose and Galactose Metabolism | 4 | 3 | 75.00 | 2 | 1 | 1.04E-02 | 3.05E-02 |
| Pentose Metabolism | 6 | 3 | 50.00 | 3 | 0 | 1.04E-02 | 3.05E-02 |
aUp indicates higher level in the post-exposure group; down indicates lower level in the post-exposure group