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. 2018 Aug 22;13:16. doi: 10.1186/s13062-018-0219-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Three signaling circuits ending in the proteins CCL19, CCL21 and GADD45B highlighted within the whole NF-kappa B signaling pathway. The circuits are significantly deactivated in patients with MYCN amplification when compared to patients without such biomarker. The results and the representation have been obtained with the program HiPathia [5]. Blue and red nodes indicate genes downregulated and upregulated, respectively. Blue arrows depict the circuits in which signal transduction is inhibited