Table 1.
Circuits that deactivate the JNK cascade in patients with MYCN amplification
| Circuit (Pathway and effector protein) | Status | FDR p-value | GO ID | GO Definition |
|---|---|---|---|---|
| Ras signaling pathway: MAPK8 | DOWN | 4.31E-29 | GO:0007254 | JNK cascade |
| Fc epsilon RI signaling pathway: MAPK8 | DOWN | 1.23E-15 | GO:0007254 | JNK cascade |
| cAMP signaling pathway: MAPK8 | DOWN | 4.72E-08 | GO:0007254 | JNK cascade |
| Apoptosis: GADD45G | DOWN | 1.07E-29 | GO:0046330 | positive regulation of JNK cascade |
| MAPK signaling pathway: MAP 4 K2 | DOWN | 1.68E-24 | GO:0046330 | positive regulation of JNK cascade |
| NF-kappa B signaling pathway: CCL19 | DOWN | 2.36E-22 | GO:0046330 | positive regulation of JNK cascade |
| NF-kappa B signaling pathway: GADD45B | DOWN | 3.83E-21 | GO:0046330 | positive regulation of JNK cascade |
| NF-kappa B signaling pathway: CCL21 | DOWN | 8.43E-16 | GO:0046330 | positive regulation of JNK cascade |
| p53 signaling pathway: GADD45G | UP | 1.70E-07 | GO:0046330 | positive regulation of JNK cascade |