Table 4.
Circuits significantly associated to bad prognostic
| Circuit (Pathway and effector protein) | Status | FDR p-val | GO ID | GO definition | Cancer hallmark |
|---|---|---|---|---|---|
| PI3K-Akt signaling pathway: BCL2L1 | UP | 5.13E-07 | GO:1900118 | negative regulation of execution phase of apoptosis | Apoptosis inhibition |
| Axon guidance: PAK4 | UP | 1.47E-05 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | Apoptosis inhibition |
| PI3K-Akt signaling pathway: BCL2L1 | UP | 0.000159 | GO:1900118 | negative regulation of execution phase of apoptosis | Apoptosis inhibition |
| Adherens junction: LEF1 CTNNB1 | DOWN | 7.35E-07 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| Apoptosis: BCL2L11 | DOWN | 2.28E-11 | GO:2000271 | positive regulation of fibroblast apoptotic process | Apoptosis inhibition |
| Apoptosis: FAS | DOWN | 3.43E-06 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| Apoptosis: FASLG | DOWN | 9.88E-11 | GO:2000353 | positive regulation of endothelial cell apoptotic process | Apoptosis inhibition |
| Apoptosis: GADD45G | DOWN | 5.11E-11 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| Apoptosis: TP53 | DOWN | 2.07E-06 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria | Apoptosis inhibition |
| Axon guidance: NCK1 PAK4 | DOWN | 0.0003919 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Apoptosis inhibition |
| ErbB signaling pathway: MYC | DOWN | 6.05E-07 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | Apoptosis inhibition |
| Hippo signaling pathway: MYC | DOWN | 0.0006402 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | Apoptosis inhibition |
| Jak-STAT signaling pathway: MYC | DOWN | 2.38E-14 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | Apoptosis inhibition |
| MAPK signaling pathway: MYC | DOWN | 1.46E-10 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | Apoptosis inhibition |
| MAPK signaling pathway: STK3 | DOWN | 2.47E-07 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| mTOR signaling pathway: RPS6 | DOWN | 2.77E-11 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| NF-kappa B signaling pathway: GADD45B | DOWN | 5.23E-07 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| NOD-like receptor signaling pathway: PYCARD CASP1 | DOWN | 7.86E-05 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | Apoptosis inhibition |
| PI3K-Akt signaling pathway: BCL2L11 | DOWN | 0.0003220 | GO:2000271 | positive regulation of fibroblast apoptotic process | Apoptosis inhibition |
| PI3K-Akt signaling pathway: FASLG | DOWN | 2.56E-12 | GO:2000353 | positive regulation of endothelial cell apoptotic process | Apoptosis inhibition |
| PI3K-Akt signaling pathway: RPS6 | DOWN | 3.43E-06 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| Ras signaling pathway: STK4 STK4 | DOWN | 0.0001864 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| T cell receptor signaling pathway: CD40LG | DOWN | 0.0002348 | GO:2000353 | positive regulation of endothelial cell apoptotic process | Apoptosis inhibition |
| Tight junction: TJP1 CTNNB1 CTNNA1 | DOWN | 0.0004428 | GO:0043065 | positive regulation of apoptotic process | Apoptosis inhibition |
| Toll-like receptor signaling pathway: CCL5 | DOWN | 1.89E-08 | GO:0070234 | positive regulation of T cell apoptotic process | Apoptosis inhibition |
| Wnt signaling pathway: MYC | DOWN | 5.12E-05 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | Apoptosis inhibition |
| Apoptosis inhibition | |||||
| Apoptosis: GADD45G | DOWN | 5.11E-11 | GO:0046330 | positive regulation of JNK cascade | Apoptosis inhibition via JNK |
| Fc epsilon RI signaling pathway: MAPK8 | DOWN | 1.78E-07 | GO:0007254 | JNK cascade | Apoptosis inhibition via JNK |
| NF-kappa B signaling pathway: GADD45B | DOWN | 5.23E-07 | GO:0046330 | positive regulation of JNK cascade | Apoptosis inhibition via JNK |
| MAPK signaling pathway: MAP 4 K2 | DOWN | 9.26E-05 | GO:0046330 | positive regulation of JNK cascade | Apoptosis inhibition via JNK |
| NF-kappa B signaling pathway: CCL21 | DOWN | 0.0001040 | GO:0046330 | positive regulation of JNK cascade | Apoptosis inhibition via JNK |
| Ras signaling pathway: MAPK8 | DOWN | 0.0003003 | GO:0007254 | JNK cascade | Apoptosis inhibition via JNK |
| Neurotrophin signaling pathway: BAX | UP | 3.02E-05 | GO:1990117 | B cell receptor apoptotic signaling pathway | Reduced immune response |
| Neurotrophin signaling pathway: BAX | UP | 3.02E-05 | GO:0001783 | B cell apoptotic process | Reduced immune response |
| p53 signaling pathway: THBS1 | UP | 3.04E-07 | GO:0030335 | positive regulation of cell migration | Metastasis |
| Wnt signaling pathway: NFATC1 | UP | 1.99E-06 | GO:0016477 | cell migration | Metastasis |
| PI3K-Akt signaling pathway: TP53 | UP | 1.17E-06 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | Proliferation |
| Ras signaling pathway: ELK1 | UP | 1.38E-06 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | Proliferation |
| Wnt signaling pathway: NFATC1 | UP | 1.99E-06 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | Proliferation |
| AMPK signaling pathway: EIF4EBP1 | UP | 0.0001405 | GO:0045947 | negative regulation of translational initiation | Proliferation |
| ErbB signaling pathway: ELK1 | UP | 0.0004442 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | Proliferation |
| Apoptosis: FASLG | DOWN | 9.88E-11 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | Proliferation |
| PI3K-Akt signaling pathway: FASLG | DOWN | 2.56E-12 | GO:0016525 | negative regulation of angiogenesis | Angiogenesis |
| HIF-1 signaling pathway: ANGPT1 | DOWN | 1.41E-11 | GO:0016525 | negative regulation of angiogenesis | Angiogenesis |
| Apoptosis: FASLG | DOWN | 9.88E-11 | GO:0016525 | negative regulation of angiogenesis | Angiogenesis |