Table 1.

LogP, P_app and UR values for troxerutin and its propionyl derivatives in Caco-2 cell monolayers

Compound	LogP	Papp AP–BL (×10−6 cm/s)	Papp BL–AP (×10−6 cm/s)	UR1
Troxerutin	− 2.04 ± 0.10	0.34 ± 0.05 d	0.35 ± 0.03 d	0.97 ± 0.07
TME	− 0.75 ± 0.08	0.99 ± 0.12 c	1.05 ± 0.12 c	0.94 ± 0.18
TDE	1.51 ± 0.05	1.54 ± 0.17 b	1.53 ± 0.21 b	1.00 ± 0.09
Rutin	− 0.58 ± 0.13	0.06 ± 0.01 e	0.06 ± 0.02 e	1.00 ± 0.05
Propranolol	–2	48.90 ± 3.30 a	44.05 ± 2.98 a	1.11 ± 4.90
Furosemide	–2	0.85 ± 0.15 c	0.86 ± 0.11 c	0.99 ± 0.13

Experiments were performed in triplicate, and data are presented as the mean ± SD. Values with different letters (a, b, c, d, e) in an assay are significantly different one from another (P < 0.05) in multiple-range analysis

¹UR = P_app AP–BL/P_app BL–AP

²Not measured