Fig. 4.

Effects of cefazolin on cytokine production at 24 h after laparotomy. Six- to 8-week-old male CD-1 mice were subjected to laparotomy with or without cefazolin. The cerebral cortex, hippocampus, blood, and colon were harvested 24 h after the surgery. a IL-6 in the brain. b IL-1β in the brain. c IL-6 and IL-1β in the serum. d IL-6 and IL-1β in the colon. Results are mean ± S.E.M. (n = 5–7). *P < 0.05 compared with control mice, ^P < 0.05 compared with mice with laparotomy