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MiR-30a significantly inhibits cell proliferation. Several important signaling pathways are involved in cell proliferation, including Wnt/β-catenin, MTDH/PTEN/Akt, and PI3K signaling pathway. Similarly, miR-30a also regulates directly the target genes, such as Eya2, HP1γ (CBX3), EZH2, IGF1R, RPA1, Notch, IRS2, SOX4, Runx2, DTL, ATF3, MYC, HIF2α, and SEPT7, which are all involved in regulating cell proliferation procedure.
