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. 2018 May 30;7:10. doi: 10.1038/s41377-018-0003-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A tunable femtosecond laser provides two synchronized pulse trains that are injected into the hollow-core fiber probe to perform CARS, SHG, and TPEF endoscopy. The light emitted by the sample is collected by and back-propagates through the same fiber (1 m long) before detection by large area photomultiplier detectors. The inset picture shows the endoscope probe head inserted into its stainless steel housing