Table 3.

Clinical differences between GPA and MPA.

	GPA	MPA
Constitutional symptoms	Common	Common
ENT disease	Common and often severe Sinusitis, epistaxis, otitis media, septal perforation, subglottic stenosis	Very mild to absent
Pulmonary involvement	Nodules, cavitatary lesions, fixed infiltrates, and pulmonary hemorrhage	Pulmonary hemorrhage
Ocular	Scleritis, episcleritis, orbital pseudotumor, uveitis, conjunctivitis	Episcleritis and conjunctivitis. Rare orbital pseudotumor
Kidney	Segmental pauci-immune necrotizing and crescentic glomerulonephritis (rare granulomatous lesions)	Segmental pauci-immune necrotizing and crescentic glomerulonephritis
Nervous system	Headache, peripheral neuropathy (rare)	peripheral neuropathy (common)
Cardiovascular	Venous thrombosis, Occasionally valvular lesions	Rare involvement.