Table 4.
Clinical features of MPA in different cohorts at presentation in the largest pediatric cohorts reported.
| Sacri et al. (3) | Cabral et al. (ARChiVe) (6) | Sun et al. (35) | Yu et al. (34) | |
|---|---|---|---|---|
| Type of study | Retrospective | Retrospective and Prospective | Retrospective | Retrospective |
| No of patients | 38 | 48 | 20 | 19 |
| M/F | 4/34 | 13/35 | 4/16 | 1/18 |
| Median age at diagnosis | 14.2 | 14 | NA | NA |
| Ethnicity | Caucasian (68%) | Caucasian (42%), Hispanics (13%) | NA | NA |
| Classification used | Watts et al (29) | EMA algorithm (6) | Revised Chapel- Hill CC (1) | Revised Chapel- Hill CC |
| CLINICAL FEATURES (%) | ||||
| Constitutional symptoms (fever, malaise, and weight loss) | 78 | 85 | 50 | 63 |
| Upper respiratory involvement (ear, nose, throat) | 0 | 0 | 0 | 10.5 |
| Lower respiratory tract involvement (hemoptysis, nodules, pulmonary hemorrhage and pulmonary infiltrates) | 30 | 44 | 15 | 52.6 |
| Renal (elevated creatinine, biopsy proven GN, abnormal urinalaysis) | 94.7 | 75 | 100 | 100 |
| Ocular (scleritis, conjunctivitis) | 7.8 | 31 | 5 | 5.2 |
| Gastrointestinal | 10.5 | 58 | 15 | 9 |
| Musculoskeletal (arthralgia, myalgia, arthritis) | 29 | 52 | 10 | 0 |
| Mucocutaneous | 34.2 | 52 | 15 | 31.5 |
| Nervous system (headache) | 5.2 | 21 | 15 | |
| Cardiovascular | 0 | 6 | 0 | 0 |