Figure 10.

100-segment model with experimental RyR2 distribution and LTCC expression based on experimentally observed axial tubules, with RyR2 hyperphosphorylation around axial tubules. (A) Model structure (left panel) and longitudinal line scan of the optimized 100-segment model (“Model”). (B–H) Comparison of SCaE characteristics (B) and whole-cell Ca²⁺-transient properties (C–H) of the model to previously published experimental data ^$Tanaka et al. (2001); ^∧Woo et al. (2002); ^&Kirk et al. (2003); ^%Loughrey et al. (2004); ^@Voigt et al. (2012); ^#Voigt et al. (2014); ^*Greiser et al. (2014).