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. 2018 Aug 14;9:1108. doi: 10.3389/fphys.2018.01108

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Copyright © 2018 Sutanto, van Sloun, Schönleitner, van Zandvoort, Antoons and Heijman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of 100-segment model. The model is represented by four different locations in the virtual cardiomyocyte. (1) Represents an RyR2 band with axial tubule and hyperphosphorylated RyR2 (indicated with “P” in the scheme) adjacent to the axial tubule, as reported by Brandenburg et al. (2016). (2) Represents an inter-band gap with axial tubule. (3) Represents an RyR2 band without axial tubule. (4) Represents an inter-band gap without axial tubule. Each segment is divided into 18 domains, as depicted in the matrix on the left, but only a subset of domains is shown for clarity. Please note the expression of RyR2 in the first and last domains in the segments located between RyR2 bands [i.e., (2) and (4)].