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. 2018 Aug 23;14(8):e1007534. doi: 10.1371/journal.pgen.1007534

Fig 1. Model of RAB-35 regulation and function during early phagosome maturation.

Fig 1

FLCN-1 activates RAB-35 downstream of an unknown signal, possibly integrin, promoting phagosome localization. RAB-35 functions parallel to CED-1 to promote the removal of PI(4,5)P and MTM-1, thus permitting the accumulation of PI(3)P. RAB-35, CED-1, and PI(3)P may promote RAB-5 recruitment and activation on maturing phagosomes. The RAB-35 effector(s) that mediate these events are not yet known and are thus depicted by dashed lines. RAB-35 would then be inactivated by TBC-10, which theoretically could be recruited by RAB-5 or other factors on the maturing phagosome.